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Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke

Recruitingn/aAges 18 Years - anyAllCentre Hospitalier Universitaire Dijon
NCT07624396 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed to thrombosis, increases the risk of thrombus formation. Once dislodged from the atrial cavity and traveling to the cerebral arteries, these thrombi can cause a cardioembolic stroke. The main risk factors for atrial cardiomyopathy (ACM) and AF are metabolic syndrome and aging. ACM is a condition that is difficult to diagnose because it is not clearly defined, except through histological analysis. Guided by the results of our experimental approaches, the investigators aim to address this challenge by examining ACM through the lens of one of its complications: cardioembolic stroke. BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor involved in infla

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📋 Eligibility rules (as published)
Inclusion Criteria: * Individuals who provided informed consent * Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI) * Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period * Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke Exclusion Criteria: * A person subject to a legal protective measure (guardianship, conservatorship) * A person subject to a judicial safeguard measure * A pregnant woman, a woman who has recently given birth, or a breastfeeding woman * An adult who is legally incapacitated or unable to give consent, * A minor
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What it tests

  • Circulating BDNF levels measured via blood sample
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Where

1 site
Chu Dijon Bourgogne
Dijon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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