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FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

Recruitingn/aAges 18 Years - anyAllUniversity of California, San Francisco
NCT07625150 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project aims to develop an \[18F\] fluorodeoxyglucose (FDG) positron emission tomography (PET) / magnetic resonance imaging (MRI) method to locate the painful inflammation in PFJ OA associated with joint loading. \[18F\] FDG PET/MRI is an emerging pain imaging approach with enhanced sensitivity to painful hypermetabolic inflammation through evaluation of intracellular glucose utilization rate via (\[18F\]FDG PET) and fine anatomy details (MRI). The investigative group has shown its promise in revealing previously unidentified or unspecified pain generators in various musculoskeletal pain conditions. The investigators have also demonstrated the feasibility of visualizing the structural changes between unloaded and loaded knee joints with MRI, which can be easily adopted in the current PET/MRI setting. The main challenge in the proposed \[18F\]FDG PET/MRI approach is to differentiate

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult with the capacity to give informed consent * Ability to perform 25 single-leg squats * No traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763) * No investigational drugs since last visit for the parent study (IRB #21-34763) * No contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763) * Not taking steroid injections * Not pregnant * Additional inclusion criteria for healthy volunteers: Minimal pain (VAS=0-1) during a series of 25 single-leg squats on one or both legs Exclusion Criteria: * Inability to consent for themselves * Inability to perform 25 single-leg squats with the study leg * New traumatic knee injuries/surgeries since last visit for the parent study (IRB #21-34763) * Taking investigational drugs since last visit for the parent study (IRB #21-34763) * New contraindications to MRI or PET tracer since last visit for the parent study (IRB #21-34763) * Taking steroid injections * Pregnant * Diabetic * Additional exclusion criteria for healthy volunteers: VAS of 2 or greater during a series of 25 single-leg squats on both legs
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What it tests

  • Not listed
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Where

1 site
UCSF Radiology China Basin
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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