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Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement

RecruitingNAAges 18 Years - anyAllGCS Ramsay Santé pour l'Enseignement et la Recher…
NCT07629388 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are: * Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room? * Does it preserve quadriceps muscle strength while improving postoperative pain control? Researchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength. Participants will: * Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery. * Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications. * Be assessed for pain,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients aged over 18 years. * Scheduled for total knee arthroplasty with multimodal analgesia. * Affiliated with or benefiting from a social security system. * Able to understand the study information and provide written informed consent. Exclusion Criteria: * Emergency surgery. * Weight under 50 kg. * Body mass index over 40 kg/m². * Contraindication to nefopam, non-steroidal anti-inflammatory drugs, local anesthetics, or morphine. * Preoperative opioid use. * Antidepressant or gabapentinoid treatment. * Other planned surgical or medical procedures during the study period. * Participation in another clinical trial, or currently in an exclusion period from another trial. * Inability to understand study information for linguistic, psychological, cognitive, or literacy reasons. * Pregnancy, possible pregnancy without effective contraception, or breastfeeding. * Protected adults, including those under guardianship, curatorship, legal protection, detention, or otherwise unable to give informed consent.
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What it tests

  • Combined distal femoral nerve block
  • Saphenous nerve block alone
  • Standard perioperative care in both groups
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Where

1 site
Hôpital privé Dijon Bourgogne
Dijon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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