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Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease

RecruitingNAAges 60 Years - anyAllCentre Hospitalier Universitaire de Saint Etienne
NCT07632755 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual support

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📋 Eligibility rules (as published)
Inclusion Criteria: Patient group: Diagnosis of Alzheimer's disease made by one of the consulting physicians-a neurologist and/or geriatrician (Dubois et al., 2014)-at the early stage, presenting with mild memory impairment of which the patient has been informed \- MMSE score of 21 or higher Control group: individuals without a diagnosis of Alzheimer's disease, but meeting the other criteria listed below * Enrollment in a social security program * Age 60 or older * French as a native language * Consent to participate Exclusion Criteria: * Uncorrected visual or hearing impairments * Language or motor impairments * Delirium or psychosis. * Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition). * Refusal to participate. * Inability to communicate * Persons deprived of liberty by a judicial or administrative decision and adults subject to a legal protection measure or unable to express their consent
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What it tests

  • Control condition
  • Motor mental imagery
  • Action execution
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Where

3 sites
Chu Grenoble
Grenoble, France
Chu de Saint Etienne
Saint-Etienne, France
HLC, Hôpital des Charpennes
Villeurbanne, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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