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Elastography-based Brief Alcohol Intervention in Hospitalized Individuals

RecruitingNAAges 18 Years - anyAllOslo University Hospital
NCT07637539 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Harmful alcohol use is a common cause of hospital admissions and the leading cause of liver cirrhosis. Timely detection of liver disease is crucial to prevent liver disease progression and reduce alcohol-related harms. The hypothesis is that proactive assessment of liver health during hospitalization may motivate reductions in alcohol use and thereby prevent disease complications and recurrent admissions more effectively than usual care. The study will recruit 500 patients at risk of alcohol-related liver disease who are admitted for inpatient care for any reason. Recruitment will be done at 8 Norwegian hospitals over an 18-month period. Participants will be randomized to liver elastography (liver stiffness measurement) and personalized alcohol counselling, or to usual care. After discharge, participants will be followed with study visits after 3, 6 and 12 months. Assessments during foll

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Emergency hospitalized for any reason in any participating centre 2. Adults 18 years or older 3. Harmful alcohol use, defined as AUDIT-C ≥6 (for men) or AUDIT-C ≥5 (for women) 4. Moderate to high risk of liver fibrosis, defined as FIB-4 \>1.3 5. Signed informed consent Exclusion Criteria: 1. Decompensated liver disease that impedes intervention delivery, defined as one or more of the following: 1. Moderate or severe ascites 2. Overt hepatic encephalopathy (West Haven grade ≥2) 3. Acute-on-chronic liver failure requiring admission to intensive care unit 2. Acute hepatitis of any aetiology, defined as ALT or AST \>5 x upper limit of normal (ULN) 3. Unable to participate for any reason in the opinion of the investigator
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What it tests

  • Elastography-based brief alcohol intervention
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Where

8 sites
Haraldsplass Deaconess Hospital
Bergen, Norway
Vestre Viken Bærum Hospital
Drammen, Norway
Sykehuset Nord-Trøndelag Levanger
Levanger, Norway
Sykehuset Innlandet Lillehammer
Lillehammer, Norway
Akershus University Hospital
Lørenskog, Norway
Diakonhjemmet Hospital
Oslo, Norway
Lovisenberg Diaconal Hospital
Oslo, Norway
Oslo University Hospital
Oslo, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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