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Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

RecruitingPhase 2Ages 60 Years - anyAllUniversity of South Carolina
NCT07638046 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful for older adults at elevated risk for ADRD. However, most existing mindful walking studies have focused on mental health outcomes, such as stress reduction, rather than cognitive health. Little is known about whether mindful walking can support cognition or how it may influence brain function. To address this gap and strengthen a future R01 resubmission, the investigators propose a two-arm randomized controlled pilot trial using functional near-infrared spectroscopy (fNIRS), a safe, non-invasive brain imaging method. fNIRS measures brain activity through sensors placed on the scalp and is well-

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 60 or older 2. Sedentary (sit ≥9hrs per day) and not meeting the US physical activity guidelines 3. Have at least one of the following ADRD risk factors: i. family history of ADRD (\>= first-degree relative) ii. subjective experience of cognitive complaints iii. currently overweight or obese (BMI≥25) 4. Adequate hearing, visual and cognitive ability to complete study tasks and assessments 5. Able to walk without others' assistance 6. Medically stable with or without medication (do not expect to have major health status changes or a surgery in the next 4 months) Exclusion Criteria: 1. Diagnosis of ADRD or other brain abnormalities (i.e., strokes, epilepsy, Parkinson's disease) 2. Diagnosis of mental disorders (i.e., depression) 3. Inability to complete surveys on mobile device or wear the activity monitor (i.e., due to arthritis, physical limitations, or other reasons) 4. Plan to move or have surgery in next 4 months 5. Currently participate in other study involving physical activity or cognitive training that may interfere with the study outcomes 6. Unable to provide consent due to disabilities
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What it tests

  • Mindfulness-based walking
  • Walking-only
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Where

1 site
University of South Carolina
Columbia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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