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Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation

RecruitingNAAges 19 Years - 100 YearsAllSamsung Medical Center
NCT07638176 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.

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📋 Eligibility rules (as published)
Inclusion Criteria: * American Society of Anesthesiologists Physical Status I - III * The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2 * Lung resection surgery requiring one-lung ventilation for over 60 minutes * Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr) * Patient who is diagnosed with intrinsic PEEP during one-lung ventilation Exclusion Criteria: * Large bullae * Emergency surgery * Mechanical ventilation before surgery * Hemodynamic instability before surgery * Surgery requiring cardiopulmonary bypass * Pregnancy, breastfeeding patient * Patient's refusal to participate * No intrinsic PEEP during one-lung ventilation
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What it tests

  • PEEP0
  • PEEP5
  • PEEPi
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Where

1 site
Samsung Medical Center
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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