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Epidemiological Characteristics and Clinical Burden of RSV Infection in Children Under 24 Months in Ho Chi Minh City (2026-2028)

Recruitingn/aAges 0 Months - 24 MonthsAllTam Anh Research Institute
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In plain words

What the trial is, and whether it could suit you

This is a prospective, observational, multicenter study employing continuous, convenience sampling, stratified by study site and by fortnightly interval, enrolling until the target sample sizes are achieved over the first epidemiological season (2026) and the second epidemiological season (2027). The study population includes children aged 0 to 24 months presenting to the outpatient or inpatient facilities of the study sites with signs and symptoms of acute respiratory infection (ARI). In Vietnam there is no single guideline for diagnosing ARI, but rather there are guidelines specific to clinical conditions such as pharyngitis, rhinitis, tonsilitis, or pneumonia. This study will use an operational definition where ARI is defined as the presence of one or more of the following clinical features: cough, rhinorrhea, sore throat, dyspnea, and / or fever. RSV testing using nasopharyngeal (NP

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Children aged 0 to \<24 months (i.e., less than two years old). * Children presenting with a diagnosis of acute respiratory infection (ARI), defined as an illness with one or more of the following symptoms: cough, rhinorrhea, sore throat, dyspnea (including wheezing, tachypnea, or apnea/increased work of breathing), sepsis (for infants aged \<6 months), and/or fever. * Children residing in the lowest administrative division (Phฦฐแปng / Xรฃ) in Vietnam that is designated for the specific study site (outpatient clinic or community hospital). As patients live in the same administrative district as the healthcare facility, this will facilitate follow-up and ensure that the study results are representative of the range of severity of ARI presenting to each specific study site. * Parent or LAR provides written informed consent for their child's participation. Exclusion Criteria: * Children whose mothers received a maternal RSV vaccine during pregnancy or who have themselves received RSV-specific monoclonal antibodies (mAbs). * Children with a known non-respiratory cause for hospitalization. * Children with respiratory symptoms lasting over 14 days. * Children hospitalized elsewhere within the preceding 4 days, excluding admission to the Emergency Department. * Children already enrolled in another RSV study within the preceding 3 months.
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What it tests

  • Not listed
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Where

3 sites
Ba Ria General Hospital
Ho Chi Minh City, Vietnam
Di An Medical Center
Ho Chi Minh City, Vietnam
Le Van Thinh Hospital
Ho Chi Minh City, Vietnam
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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