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Effect of Lidocaine Through Gastric Tube on PONV

RecruitingNAAges 18 Years - 65 YearsAllGeneral Hospital of Ningxia Medical University
NCT07643298 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is: Does administering 0.5% lidocaine via an orogastric tube reduce the incidence of postoperative nausea and vomiting (PONV) in the post-anesthesia care unit and within the first 24 hours after surgery compared to a placebo (normal saline)? Researchers will compare the Lidocaine Group to the Placebo Group to see if the intervention lowers the PONV incidence. Participants will: * Receive the assigned study solution (either 0.5% lidocaine 20ml or normal saline 20ml) through an orogastric tube upon surgery completion and before extubation. * Have their gastric tube clamped for 5 minutes to ensure mucosal exposure before removal. * Undergo standardized total i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged between 18 and 65 years old; * American Society of Anesthesiologists (ASA) physical status classification II - III; * Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia; * Capable of giving informed consent. Exclusion Criteria: * Known allergy, hypersensitivity or contraindication to lidocaine or amide - type local anesthetics; * Previous significant liver or kidney dysfunction (e.g., ALT/AST \> 3 times the upper limit of normal, GFR \< 30 mL/min); * History of epilepsy, cardiac conduction abnormalities or previous diagnosis of malignant hyperthermia; * Pregnancy or lactation; * Patients who received systemic lidocaine treatment during the operation; * History of severe postoperative nausea and vomiting (PONV) or motion sickness, requiring multiple prophylactic medications; * Emergency or revision bariatric surgery.
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What it tests

  • Lidocaine
  • Normal Saline (0.9% NaCl)
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Where

1 site
General Hospital of Ningxia Medical University
Yinchuan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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