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Impacts of HIV Treatment Regimens on Archived Drug Resistance

Recruitingn/aAges 18 Years - anyAllChinese University of Hong Kong
NCT07643948 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study aims to determine the prevalence of drug resistance mutation (DRM) in virally suppressed HIV infection, and the impacts of regimen change and the presence of low level viremia. Adults living with HIV infection on antiretroviral therapy (ART) with full viral suppression would be recruited. Cases are patients planning for regimen switch, while controls are those with and without low level viraemia (LLV) not planned for switch. Blood samples would be collected before and after switch. Sequencing would be performed to identify DRM present in HIV-1 proviral DNA.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients living with HIV who are (a) aged 18 or above, (b) on antiretroviral therapy, (c) has viral load \<20 copies/mL at 2 time points for ≥6 months, (d) planning regimen switch. * Patients for inclusion in the control group meet the same criteria (a) but they are not planned for switch. Controls include patients with low level viremia (LLV) as defined as ≥2 consecutive viral load level between 21 and 200 copies/mL in the preceding 2 years. Exclusion Criteria: * Patients living with HIV who (a) are pregnant, (b) have virologic failure, (c) are suffering from concurrent opportunistic infections, (d) are prisoners , (e) are unable to give consent, and (f) have mental illnesses.
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What it tests

  • Not listed
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Where

1 site
S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong
Hong Kong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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