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← Trials
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Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease

Recruitingn/aAges 18 Years - anyAllShmuel Kivity, MD
NCT07644117 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational study aims to identify genes that may affect how patients with inflammatory bowel disease respond to anti-TNF treatment and why some patients lose response to treatment over time. The study will examine whether genetic markers can help predict which patients are more likely to respond to anti-TNF therapy. Participants who have not previously received anti-TNF treatment and are about to start advanced therapy will provide a blood sample to test for the genetic markers. Participants will also undergo regular assessments of current treatment, disease activity, and inflammatory markers during follow-up.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Established IBD: Crohn's disease (CD) or ulcerative colitis (UC) * Anti-TNF naïve * Clinically active disease (HBI\>5 for CD, p-MS≥ 3 for UC) * Elevated inflammatory indices CRP\>10 or fecal calprotectin\>250 Exclusion Criteria: * Unable to provide informed consent * Anti-TNF experienced * Unable to complete the study protocol
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What it tests

  • This is an observational study with no intervention. Patients will receive anti- TNF therapy as part of their standard care
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Where

1 site
Dep. of Gastroenterology, Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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