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SBRT-LATTICE-PATHY

RecruitingPhase 2Ages 18 Years - anyAllUniversity of Sao Paulo General Hospital
NCT07645261 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To assess the importance of using SBRT-LATTICE-PATHY for the radiotherapy treatment of large tumors that would be considered intractable by currently used standard techniques. In this present study, the investigators will have the possibility of combining SBRT and LATTICE techniques, incorporating the concept of hypoxic tissue irradiation, which are potential modulators of abscopal and bystander effects, performing partial punctual treatment in the vertex region, without the need for irradiation of the entire tissue volume, further improving safety in relation to possible toxicities.

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📋 Eligibility rules (as published)
Inclusion Criteria: * age =or\> 18 years; * Eastern Cooperative Oncology Group (ECOG) performance status \< 2; benign and malignant tumors for which the use of radiotherapy is well established in the literature; * tumors =or\> 340 cm³ or with a largest diameter =or\> 7 cm; * no indication for any other type of treatment due to lack of proven clinical benefit (surgery, chemotherapy, standard radiotherapy, immunotherapy, targeted therapy, etc.); * Palliative Prognostic Index (PPI) =or\< 2; * metastatic disease in the central nervous system (CNS), if present, controlled (up to 3 metastases, each up to 1 cm); * up to 5 extracranial distant metastases (nodal or extranodal) =or\< 5 cm; signed Informed Consent Form (ICF). Exclusion Criteria: * cases in which tumor volume and/or the patient's clinical condition make adequate immobilization/simulation impossible; * previous local radiotherapy; * pregnant patients; * autoimmune diseases; * genetic instability syndromes; * ongoing systemic therapy; * renal insufficiency that prevents the use of iodinated contrast.
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What it tests

  • SBRT-LATTICE-PATHY
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Where

1 site
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Radiologia
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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