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Use of Continuous Glucose Monitoring to Evaluate Postprandial Response to Raw Cornstarch Supplementation in Adult Glycogen Storage Disease Type I

Recruitingn/aAges 18 Years - anyAllFederico II University
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In plain words

What the trial is, and whether it could suit you

The aim of this observational study is to evaluate the impact of raw cornstarch supplementation on postprandial glycemic response in adult patients with Glycogen Storage Disease type I (GSD I), using continuous glucose monitoring (CGM) systems.GSD I is a rare inherited metabolic disorder characterized by impaired glucose homeostasis during fasting, leading to recurrent hypoglycemia and metabolic abnormalities. Nutritional therapy, based on frequent carbohydrate intake and raw cornstarch supplementation, represents the cornerstone of treatment. However, the optimal timing of raw cornstarch administration in relation to meals and its effect on postprandial glycemic control remain unclear.The main question this study aims to answer is: "Does raw cornstarch intake during meals affect postprandial glycemic response in adult patients with Glycogen Storage Disease type I?". Additional objective

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * confirmed genetic diagnosis of GSD Ia or Ib; * age \>18 years; * routine CGM use; * habitual raw cornstarch consumption. Exclusion Criteria: * psychiatric disorders; * pregnancy, celiac disease; * dialysis treatment; * nocturnal enteral feeding; * severe acute or chronic illnesses.
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What it tests

  • Not listed
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Where

1 site
AOU Policlinico "Federico II"
Naples, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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