A Phase 1b/2 Study of Ropeginterferon Alfa-2b Added to Azacitidine in MDS/AML With TP53 Mutations

Eligibility Criteria Participants with following: I) Adult participants with MDS/AML with TP53 aberration * TP53 aberration defined by: * Single TP53 mutation\> 10% VAF * \>1 mutation of any VAF, irrespective of cytogenetics or TP53 allele loss * Single TP53 mutation 5-10% with complex karyotype and/or TP53 allele loss * (TP53 mutation will include any known or possible pathogenic missense, truncating or splicing mutations in the UT MD Anderson CLIA lab myeloid NGS panel and validated by molecular pathologist; TP53 allele loss on FISH should be at least \> 5%) a. Cohort1A: R/R MDS/AML ≥ 18years of age, irrespective of eligibility of intensive therapy i) ≥5% blasts in the bone marrow and/or peripheral blood. b.Cohort1B: Newly diagnosed MDS/AML and Ineligible for intensive chemotherapy defined by: i) ≥ 10% blasts ii) Ineligible for intensive chemotherapy * Adult patients ≥ 60 years of age, OR * Adult patients 18 to 60 years of age with at least one of the following relevant clinical situations/status: * Eastern cooperative oncology group (ECOG) performance status ≥2 * Clinically significant organ comorbidities, as reflected by at least 1 of: * Left ventricular ejection fraction (LVEF) \</= 50% * Chronic stable angina or congestive heart failure controlled with medication * Creatinine clearance \< 45 ml/min calculated by the Cockcroft-Gault formula or measured by 24 hours' urine collection * Impaired pulmonary function: Lung diffusing capacity for carbon monoxide (DLCO) ≤65% of expected * Forced expiratory volume in 1 second (FEV1) ≤65% of expected * Other contraindication(s) to anthracycline therapy (must be documented). * Other comorbidity the investigator judges incompatible with intensive remission induction chemotherapy, which must be documented and approved by the PI. II) Adequate hepatic function defined by * Serum AST/ALT ≤ 3 x ULN, unless considered due to leukemic organ involvement. * Serum total bilirubin \< 2x ULN. Higher levels are acceptable if these can be attributed to ineffective erythropoiesis, leukemia organ involvement or Gilbert's syndrome. * The teratogenic effect of AZA and ropeginterferon is not well studied. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. (Refer to Pregnancy Assessment Policy UT MD Anderson Institutional Policy # CLN1114). This includes all female patients, between the onset of menses (as early as 8 years of age) and 55 years unless the patient presents with an applicable exclusionary factor which may be one of the following: * Postmenopausal (no menses in greater than or equal to 12 consecutive months). * History of hysterectomy or bilateral salpingo-oophorectomy. * Ovarian failure (Follicle Stimulating Hormone and Estradiol in menopausal range, who have received Whole Pelvic Radiation Therapy). * History of bilateral tubal ligation or another surgical sterilization procedure. Approved methods of birth control are as follows: Hormonal contraception (i.e. birth control pills, injection, implant, transdermal patch, vaginal ring), Intrauterine device (IUD), Tubal Ligation or hysterectomy, Subject/Partner post vasectomy, Implantable or injectable contraceptives, and condoms plus spermicide. Not engaging in sexual activity for the total duration of the trial and the drug washout period is an acceptable practice; however periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of birth control. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Contraception should be continued for at least 4 months from the last dose of AZA and/or ropeginterferon administration. • Men treated or enrolled on this protocol must also agree to use adequate contraception, for the duration of study participation, and 4 months after completion of AZA and/or ropeginterferon administration. III) For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. IV) Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load. V) Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. VI) Patients with a prior or concurrent malignancy may be eligible after discussion with the investigator/ PI. VII) Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria I) For Cohort 1A and 1B 1. Adult patients with MDS/AML without a known pathogenic TP53 mutation 2. Patients with immediate life-threatening, severe complications of leukemia such as uncontrolled bleeding, pneumonia with hypoxia or shock, and/or disseminated intravascular coagulation. 3. Patient with active uncontrolled systemic fungal, bacterial, or viral infection (defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment). 4. Patient with known and untreated major depressive disorder 5. Recent stroke or myocardial infarction (in previous 6 months) 6. Patient with known retinal disease except for known age related macular degeneration 7. Patient with another active cancer warranting therapy. A maintenance therapy for a stable/treated prior cancer is acceptable if it does not interfere with the trial therapy. This needs to be discussed with the PI. 8. Patients who are receiving any other leukemia treatment. 9. Patients who are receiving any other investigational agent