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Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

RecruitingNAAges 55 Years - 75 YearsAllFlorida State University
NCT07649005 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are: 1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults. 2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex. Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ages 55-75 years * At least one-year post-menopause (females) * Willing and able to attend laboratory visits Exclusion Criteria: * BMI ≥35 kg/m2 * Seated blood pressure \>135/85 mmHg * Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke) * Taking exogenous hormones or hormone replacement therapy * Following a vegan or gluten free diet * Significant weight loss (\>10% of body weight) in the last 6 months, or actively trying to lose weight * Current or recent use of a diuretic (within the past 6 months) (e.g. spironolactone, eplerenone) * Current or recent use of a potassium binding medication (within the past 6 months) * Current use of blood pressure lowering medications (e.g. ACE inhibitors, calcium channel blockers, diuretics, vasodilators, beta blockers, AngII receptor blockers) * Current or recent use of the medication trimethoprim * Elevated blood lipids (LDL cholesterol ≥190 mg/dL) * Elevated serum potassium level (\>5.1 mmol/L) * Elevated BUN (\>22 mg/dL) * Elevated creatinine (\>1.2 mg/dL) * Low eGFR (\<90 mL/min/1.73 m²) * Current or recent use of tobacco, nicotine, or illicit drugs * Radical hysterectomy or oophorectomy (females)
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What it tests

  • low sodium/low potassium diet
  • high sodium/low potassium diet
  • high sodium/high potassium diet
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Where

1 site
Florida State University
Tallahassee, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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