Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism

Inclusion Criteria: 1. Adults (between 18 and 65 years old) 2. Without a current psychiatric diagnosis assessed by a structured psychiatric interview at the screening/consent visit 3. Without a history of a psychotic disorder and/or mood disorder among parents, siblings, or children Exclusion Criteria: 1. Any current significant medical or neurological illness. 2. Diagnosis of diabetes mellitus (DM), uncontrolled hypertension (HTN), severe hypotension, coronary artery disease (CAD), metabolic syndrome, glaucoma, liver impairment, decreased renal function, respiratory disorders, and uncontrolled peptic ulcer disease. 3. Currently taking any other medications, including over-the-counter supplements except oral contraceptives for women and Tylenol as needed for pain or headache. 4. Currently pregnant or breastfeeding. Females of child-bearing age must be using an effective contraceptive method. 5. History of substance abuse or dependence. 6. Contraindication to MR scan (claustrophobia, cardiac pacemakers, metal clips and stents on blood vessels, artificial heart valves, artificial arms, hands, legs, etc., brain stimulator devices, implanted drug pumps, ear implants, eye implants or known metal fragments in eyes, exposure to shrapnel or metal filings, other metallic surgical hardware in vital areas, certain tattoos with metallic ink, certain transdermal patches, metal- containing IUDs) 7. Medical condition that would prevent blood draws, including current anti-coagulant or anti-aggregant therapy, tendency for abnormal scarring (e.g., keloids). 8. Difficulty in swallowing capsules.