Immiseal™ Dural Sealant Post-Market Registry Study

Inclusion Criteria: 1. Age 18 to 75 years old, regardless of gender. 2. Patients diagnosed with craniocerebral trauma, brain tumour, cerebrovascular disease, congenital disease of the nervous system, or spinal canal disease, who undergo neurosurgical procedures such as posterior fossa surgery or other interventions resulting in dural defects, whether due to surgery or accidental injury, and who present with, or are at risk of, cerebrospinal fluid (CSF) leakage requiring auxiliary dural repair. 3. Patients willing to comply with the requirements of the clinical investigation by signing the informed consent. 4. Female patients of childbearing potential must use highly effective contraceptive methods for the duration of the study. Highly effective contraceptive methods include hormonal contraception, intrauterine device, or sexual abstinence. Exclusion Criteria: 1. Immiseal™ Dural Sealant System is not to be used in confined bone structures where nerves are present, since neural compression may result due to hydrogel swelling. 2. Patients with an active infection present at the surgical site. 3. Patients with life expectancy less than 3 months. 4. Female patients who are pregnant, planning pregnancy, breastfeeding, and/or unwilling to use adequate contraception during the trial.