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โ† Trials
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A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

RecruitingPhase 2Ages 40 Years - anyAllAstraZeneca
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In plain words

What the trial is, and whether it could suit you

This Phase IIb study aims to evaluate the efficacy, safety, and tolerability of 3 doses of AZD8965 treatment compared to placebo in participants with IPF, including those on antifibrotic therapy (nintedanib, pirfenidone, nerandomilast), either alone or in combination, or in those not on antifibrotic therapy.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age โ‰ฅ 40 years 2. IPF diagnosis 3. Participants with IPF receiving locally approved antifibrotic therapies at a stable dose, or participants with IPF not receiving local standard of care 4. FVC โ‰ฅ 45% predicted of normal 5. DLCO corrected for hemoglobin โ‰ฅ 25% predicted of normal Exclusion Criteria: 1. ILD other than IPF 2. The extent of emphysema is greater than the extent of fibrotic changes on chest HRCT scan 3. Acute exacerbation of IPF 4. Lower respiratory tract infection requiring treatment 5. Acute coronary syndrome/acute myocardial infarction, unstable angina ยฑ coronary intervention with Percutaneous Coronary Intervention, or Coronary Artery Bypass Grafting 6. Heart failure 7. History of organ transplantation or is likely to receive lung transplantation
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What it tests

  • Placebo for AZD8965
  • AZD8965 low dose
  • AZD8965 medium dose
  • AZD8965 high dose
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Where

195 sites
Research Site
Birmingham, United States
Research Site
Phoenix, United States
Research Site
Phoenix, United States
Research Site
Loma Linda, United States
Research Site
Los Angeles, United States
Research Site
Newport Beach, United States
Research Site
Sacramento, United States
Research Site
Stanford, United States

โ€ฆand 187 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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