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A Study Comparing Carotid Doppler Ultrasound and Echocardiography to Assess Fluid Responsiveness in Septic Patients on Ventilator

RecruitingNAAges 12 Years - anyAllPakistan Institute of Medical Sciences
NCT07653568 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. The study will compare this method with transthoracic echocardiography-derived cardiac output, which is a commonly used non-invasive technique for assessing hemodynamic status in critically ill patients. The study also aims to evaluate whether carotid artery ultrasound can provide a faster and more practical bedside assessment during fluid resuscitation in the intensive care unit. In patients with sepsis, giving too little intravenous fluid may worsen organ perfusion and shock, while excessive fluid administration may lead to complications such as pulmonary edema, worsening oxygenation, prolonged mechanical ventilation, and longer intensive care unit stay. Because of thi

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📋 Eligibility rules (as published)
Inclusion Criteria: * • Adults with sepsis requiring mechanical ventilation in the intensive care unit * Patients requiring fluid assessment or fluid resuscitation based on clinical findings, including one or more of the following: * Heart rate greater than 100 beats per minute * Systolic blood pressure less than 90 mmHg * Mean arterial pressure less than 65 mmHg * Urine output less than 0.5 mL/kg/hour for at least 2 hours Exclusion Criteria: * Intracranial pathology associated with raised intracranial pressure, including intracerebral hemorrhage or space-occupying lesions * Recent neurosurgical procedures or conditions where passive leg raising may increase intracranial pressure * Known heart failure * Significant cardiac arrhythmias * Significant valvular heart disease * Status asthmaticus * Pulmonary hypertension * Pulmonary embolism * Pregnancy * Lower limb conditions preventing passive leg raising, including fractures * Intra-abdominal hypertension * Recent abdominal surgery * Known carotid artery disease or common carotid artery stenosis greater than 50%
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What it tests

  • intravenous crystalloid fluid bolus
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Where

1 site
Pakistan Institute Of Medical Sciences
Islamabad, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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