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Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock

Recruitingn/aAges 18 Years - anyAllPeking Union Medical College Hospital
NCT07653659 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult distributive shock patients aged ≥18 years; 2. Receiving norepinephrine infusion with MAP in the 75-85 mmHg range; 3. PiCCO catheter in situ; 4. Under mechanical ventilation; 5. Clinically indicated norepinephrine dose reduction per attending physician judgment. Exclusion Criteria: 1. Significant cardiac arrhythmia affecting CO measurement reliability; 2. Contraindication to airway plateau pressure maneuver; 3. Active titration of other vasoactive agents within 30 minutes prior to measurement; 4. Hemodynamic instability making it impossible to reduce norepinephrine dose.
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What it tests

  • Not applicable- observational study
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Where

1 site
Peking Union Medical College Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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