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Tissue Adhesive Versus Sutures in Oral Biopsy Closure

RecruitingNAAges 18 Years - 80 YearsAllDamascus University
NCT07654166 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Excisional biopsies are commonly performed in the oral mucosa, and proper wound closure and hemostasis are critical for the success of the surgical procedure. Suturing remains the gold standard for closing surgical incisions; however, it has several drawbacks, including being time-consuming and requiring technical skill for proper placement. In addition, access to posterior areas of the oral cavity can be challenging. Suturing may also cause patient discomfort during needle penetration of tissues and can serve as a potential pathway for microbial contamination. Therefore, this randomized controlled clinical trial aims to evaluate one of the latest tissue adhesives from the cyanoacrylate group (PeriAcryl 90 HV) compared to conventional surgical sutures (Nylon 4-0) for wound closure following oral excisional biopsies. A total of 28 patients with oral fibroma will be randomly assigned to ei

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📋 Eligibility rules (as published)
Inclusion Criteria: -Patients clinically diagnosed with oral fibroma located on the labial mucosa (lip) or buccal mucosa (cheek). * Lesion requires excisional biopsy. * Lesion size greater than 3 mm and less than 3 cm in greatest diameter. Exclusion Criteria: * Pregnant or breastfeeding women. * Patients taking anticoagulant medications (blood thinners). * Patients with infectious diseases such as hepatitis, HIV, etc. * Patients taking immunosuppressants. * Patients with uncontrolled diabetes mellitus. * Patients taking medications that affect bleeding and wound healing.
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What it tests

  • Tissue adhesive (PeriAcryl 90 HV)
  • Surgical suture (Nylon 4-0)
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Where

1 site
Damascus University ,Department of Oral Medicine, Faculty of Dentistry
Damascus, Syria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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