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A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

RecruitingPhase 3Ages 18 Years - 79 YearsAllGasherbrum Bio, Inc., a wholly owned subsidiary o…
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In plain words

What the trial is, and whether it could suit you

This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatment.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Signed Informed Consent * Have a BMI ≥27.0 kg/m2 at Screening * Have a diagnosis of T2DM according to the WHO classification or other locally applicable standards, with HbA1c ≥6.5% (≥53 mmol/mol) to ≤10% (86 mmol/mol) at Screening Exclusion Criteria: * Have type 1 diabetes, history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2DM. * Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 180 days prior to Screening. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Self-reported change in body weight \>5 kg (11 pounds) within 3 months before Screening. * Have prior or planned surgical or non-surgical treatment for obesity.
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What it tests

  • aleniglipron
  • aleniglipron
  • aleniglipron
  • Placebo
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Where

74 sites
ACCOMPLISH-2 Research Site
Birmingham, United States
ACCOMPLISH-2 Research Site
Chandler, United States
ACCOMPLISH-2 Research Site
Phoenix, United States
ACCOMPLISH-2 Research Site
Sun City West, United States
ACCOMPLISH-2 Research Site
Tucson, United States
ACCOMPLISH-2 Research Site
Little Rock, United States
ACCOMPLISH-2 Research Site
Escondido, United States
ACCOMPLISH-2 Research Site
Fountain Valley, United States

…and 66 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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