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The Impact of Anaesthesia and Sedation on Inflammation and NETosis in Hepatocellular Carcinoma Ablation

RecruitingNAAges 18 Years - 80 YearsAllIuliu Hatieganu University of Medicine and Pharma…
NCT07657897 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

According to recent literature, liver disease causes approximately 2 million deaths annually; 1 million are attributed to the complications of cirrhosis, while the remaining deaths are caused by hepatocellular carcinoma (HCC). The latter currently ranks 16th among the leading causes of death worldwide. Current research focuses on investigating novel therapeutic modalities, optimizing surgical and anesthetic practices, and identifying biological biomarkers to predict disease progression and severity. In this study, we address radiofrequency ablation (RFA) with the goal of improving periprocedural prognosis, recurrence rates, and overall survival. Specifically, we will quantify the expression of NETosis, a relatively novel biomarker with potential therapeutic and prognostic value in HCC progression. NETosis is a regulated form of cell death through which granulocytes release decondensed c

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients with a hepatocellular carcinoma suitable for RFA * tumor measuring up to 3 cm in diameter * ASA I, II, or III Exclusion Criteria: * candidates for surgery * chronic immunosuppressive medication * contraindications to any of the study medications * patients with psychiatric disorders * autoimmune disorders * corticosteroid-dependent bronchial asthma * congenital or acquired coagulation disorders * HIV-positive patients * pregnant women * antiarrhythmic therapy
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What it tests

  • Sedation using combination of Propofol and Fentanyl.
  • Sedation using combination of Propofol and Fentanyl and lidocaine
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Where

1 site
"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Cluj-Napoca, Romania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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