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โ† Trials
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Electrical Nerve Stimulation During Sleep for Memory Consolidation

RecruitingNAAges 18 Years - 35 YearsAllXidian University
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to investigate the effects of transcutaneous electrical nerve stimulation (eTNS) applied during sleep on memory consolidation and brain-body physiological coupling. Healthy college students will participate in four overnight sleep sessions in a standard sleep laboratory. Before going to sleep, participants will learn and complete two cognitive tasks: a motor sequence tapping task to assess procedural memory, and an N-back task to assess working memory. During the night, participants will receive either 2 Hz eTNS, 120 Hz eTNS, or a sham (placebo) stimulation on their forehead in a randomized order. Throughout the night, researchers will record their sleep using polysomnography (PSG), along with continuous monitoring of heart rate (ECG) and breathing (respiration). Upon waking the next morning, participants will be re-tested on both memory tasks. The primary

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Healthy young adults (e.g., college students), aged generally between 18 and 30 years. 2. Right-handed. 3. Body Mass Index (BMI) โ‰ค 30 kg/m\^2. 4. Capable of fully comprehending the experimental procedures and voluntarily signing the informed consent form. Exclusion Criteria: 1. History or current presence of neurological disorders, psychiatric disorders, or brain damage. 2. History or current presence of cardiovascular diseases (e.g., arrhythmias or abnormal nocturnal heart rate). 3. Presence of depressive or anxiety symptoms (assessed by Patient Health Questionnaire-9 \[PHQ-9\] score \> 9, or Generalized Anxiety Disorder-7 \[GAD-7\] score \> 9). 4. Presence of sleep disturbances or poor sleep quality (assessed by Insomnia Severity Index \[ISI\] score \> 8, or Pittsburgh Sleep Quality Index \[PSQI\] score \> 10). 5. Any medication use within the past six months that could affect stress responses, cognitive abilities, or sleep architecture. 6. History of smoking or alcohol abuse. 7. Known skin allergies to conductive paste, medical tape, or silicone electrodes. 8. Female participants who are in their menstrual period during the scheduled experimental sessions (sessions must be strategically scheduled to avoid this period). 9. Inability or refusal to abstain from caffeine, tea, and alcohol for at least 24 hours prior to and during the experimental sessions.
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What it tests

  • 120 Hz Transcutaneous Electrical Nerve Stimulation
  • 2 Hz Transcutaneous Electrical Nerve Stimulation
  • Sham Stimulation (Placebo)
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Where

1 site
Xidian University
Xi'an, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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