💬In plain words
What the trial is, and whether it could suit you
The purpose of this clinical study is to evaluate and compare how well three different types of toothpaste technologies work to relieve tooth sensitivity, also known as dentin hypersensitivity. The study asks the question: How effective are toothpastes containing 8% Arginine, 8% Arginine with Zinc Phosphate, or 5% Calcium Sodium Phosphosilicate (CSPS) at providing immediate and short-term relief for people suffering from sensitive teeth?
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
1. Sign an Informed Consent Form;
2. Male or female 18 to 70 years of age, inclusive;
3. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc);
4. Willingness to provide information related to their medical history;
5. Available for the two (2) weeks duration of the study;
6. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns);
7. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria:
1. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession;
2. Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale.
Exclusion Criteria:
1. Gross oral pathology, chronic disease, and/or history of allergies to any of the test products;
2. Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past month prior to start of the study;
3. Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted;
4. Sensitive teeth with a mobility greater than one;
5. Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;
6. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation;
7. Current smokers and subjects with a history of alcohol or drug abuse;
8. Participation in any other oral clinical study for the duration of this study;
9. Self-reported pregnancy and/or currently breastfeeding;
10. Allergies to oral care products, personal care consumer products, and/or their ingredients;
11. Medical condition which prohibits not eating/drinking for 4 hours.
12. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study;
13. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine);
14. Current use of orthodontic appliances (including fixed braces, clear aligners, or permanent retainers)
HealthTeky