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Metabolic Reprogramming and Microenvironment in Pancreatic Adenocarcinoma

Recruitingn/aAges 18 Years - anyAllInstitut Paoli-Calmettes
NCT07664891 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present project aims to elucidate the metabolic interactions within the tumor microenvironment of pancreatic adenocarcinoma, both in the primary tumor and in hepatic and pulmonary metastatic sites, as well as in circulating blood biomarkers. Deciphering these complex interactions aims to identify exploitable vulnerabilities for predicting treatment efficacy or for guiding therapeutic strategies.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age \> 18 years 2. Signed written informed consent specific to the PROMETAP study 3. Affiliation with a social security system 4. Treatment and follow-up performed at the Institut Paoli-Calmettes 5. Metastatic PDAC requiring biopsy as part of routine care (group1 and 2) 6. Prior treatment: * No previous chemotherapy for the "initial" group * No prior chemotherapy in the metastatic setting for the "Metastatic Relapse" group 7. Eligible for chemotherapy (ECOG \< 2) Non-Inclusion Criteria: 1. Contraindication to biopsy of the pancreatic tumor or a hepatic or pulmonary metastasis (group 1 and 2) 2. Absence of a metastasis accessible to biopsy (group1 and 2) 3. Concurrent treatment for another active cancer 4. Pregnant or breastfeeding women 5. Patients in emergency situations 5\. Adult individuals under legal protection (guardianship, trusteeship, judicial protection) or unable to provide informed consent
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What it tests

  • Biopsy collection
  • Blood collection
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Where

1 site
Institut Paoli-Calmettes
Marseille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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