🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension

RecruitingNAAges 18 Years - 80 YearsAllChinese University of Hong Kong
NCT07665034 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Background: Hypertension (HT) is the most common condition worldwide, predisposing to atherosclerotic disease. However, most HT patients have suboptimal BP control despite anti-HT medications. Isometric resistance exercise (IRE) (e.g. wall squat) may improve BP control, characterized by sustained muscle contraction with minimal change in muscle length and joint angle. Most randomized trials of IRE are short duration and their long-term effects on BP and atherosclerotic complications, particularly in the Chinese, remain unknown. Study objectives: (i) To evaluate the impact of IRE on atherogenesis surrogates (brachial flow-mediated dilation, FMD and carotid intima-media thickness IMT). (ii) To evaluate the impact of IRE on mechanisms of atherogenesis improvement, inflammatory parameters, arterial wall stiffness and biochemical profiles. Setting: Randomized samples of 200 HT patients,

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: 1. asymptomatic clinically stable adults 2. aged \>18 years 3. Both genders 4. Suboptimal BP (on stable medication) with SBP 135-160mmHG on ambulatory BP monitoring (AMBP) 5. Agreeable to no drug changes in coming 1 year 24 weeks 6. Agreeable to provide informed written consent form 7. Agreeable to have AMBP and ultrasonic (FMD \& IMT) scan third (baseline, 24 weeks and preferably 1 year) Exclusion Criteria: 1. relative contraindications to AMBP (e.g. atrial fibrillation) 2. severe osteoarthritis of knee 3. known secondary HT 4. pregnancy/breastfeeding 5. active malignancy 6. Serious coronary profiles, (unstable angina), renal or hepatic derangement 7. Need to change medications for control BP at 24 weeks ( SBP\>160 mmHg)
💊

What it tests

  • Squatting Exercise
  • Stretching (Yoga) Exercise
📍

Where

1 site
The Chinese University of Hong Kong, Department of Medicine & Therapeutics
Shatin, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy