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Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss

Recruitingn/aAges 18 Years - 65 YearsAllRecep Tayyip Erdogan University Training and Rese…
NCT07666126 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism. A total of 80 individuals aged 18-65 years will be included in

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📋 Eligibility rules (as published)
Inclusion Criteria: * Being between 18 and 65 years of age * Being systemically healthy or diagnosed with hyperuricemia * Having at least 20 natural teeth * Being periodontally healthy or diagnosed with periodontitis Exclusion Criteria: * Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism. * Smoking * Pregnancy or lactation * Having received periodontal treatment within the last 3-6 months * Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs * Presence of systemic diseases that may affect purine metabolism
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What it tests

  • Collection of gingival crevicular fluid (GCF) and serum samples
  • Measurement of periodontal clinical parameters
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Where

1 site
Recep Tayyip Erdoğan University
Rize, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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