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A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

RecruitingPhase 3Ages 18 Years - anyAllNovo Nordisk A/S
NCT07668414 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.
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What it tests

  • Zenagamtide
  • Semaglutide
  • Placebo (matched to semaglutide)
  • Placebo (matched to zenagamtide)
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Where

45 sites
First Valley Medical Group
Lancaster, United States
Desert Oasis Healthcare
Palm Springs, United States
Western University of Health Sciences
Pomona, United States
Artemis Insitute for Clin Res
San Diego, United States
Med Home Development Grp
Washington D.C., United States
Encore Medical Research LLC
Hollywood, United States
NextPhase Research
Hollywood, United States
Jacksonville Ctr Clin Res
Jacksonville, United States

…and 37 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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