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Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia

RecruitingPhase 4Ages 65 Years - 80 YearsAllGeneral Hospital of Ningxia Medical University
NCT07670923 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale will be used to evaluate sedation depth. This study aims to assess the effects of ciprofol and propofol on hemodynamics and respiratory function in elderly patients undergoing non-intubated general anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients scheduled for elective non-intubated general anesthesia 2. Age ranging from 65 to 80 years old 3. American Society of Anesthesiologists (ASA) physical status class I-III 4. Written informed consent signed by the patient or legal guardian Exclusion Criteria: 1. Confirmed allergy to propofol, ciprofol or their excipients 2. Severe cardiovascular diseases (uncontrolled hypertension, heart failure, severe arrhythmia, etc.) 3. Severe respiratory diseases (chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, etc.) 4. Severe hepatic or renal insufficiency 5. Long-term regular use of sedatives or opioids 6. Baseline bradycardia (HR \< 50 beats/min) or hypoxemia (SpO₂ \< 90%)
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What it tests

  • Propofol Injection
  • Ciprofol Injection
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Where

1 site
Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University
Yinchuan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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