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Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments

RecruitingNAAges 18 Years - 65 YearsAllMedipol University
NCT07671326 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 65 years * Being systemically healthy (ASA I or ASA II) * Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region * Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form Exclusion Criteria: * Patients who have received antibiotics or corticosteroids within the last 3 months * Patients with systemic diseases * Teeth that cannot be properly isolated with a rubber dam * Teeth with periodontal pockets \>4 mm and teeth with crown/root fractures * Individuals who are undergoing or planning to start orthodontic treatment during the study period * Pregnant or breastfeeding individuals
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What it tests

  • Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament
  • Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
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Where

1 site
Istanbul Medipol University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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