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Transfusion-Related Changes in Oxidative Stress Biomarkers in Neonates

Recruitingn/aAges 5 Minutes - 5 MonthsAllMedical University of Graz
NCT07672275 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Reactive oxygen species (ROS), which include peroxides, are generated in the human body as by-products of cellular metabolism. In small amounts, they fulfill important physiological functions. However, when produced in excess, they can damage cells and tissues. Extremely low gestation age neonates (ELGANs) are particularly vulnerable to such harmful effects because their antioxidant defense systems are immature, and they are exposed to increased ROS levels due to the oxygen therapy required after birth. Fetal hemoglobin (HbF), the primary oxygen carrier in the blood of newborns, plays a crucial role in this context. Compared with adult hemoglobin (HbA), it has a higher oxygen affinity and a more pronounced pseudoperoxidase activity, which helps protect organs during early development from peroxides. In addition to oxygen administration, blood transfusions can also contribute to increas

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📋 Eligibility rules (as published)
Inclusion Criteria: Part A: * Neonates who are monitored on the NICU immediately after birth * Written parental informed consent Part B: * Term and preterm neonates admitted to the NICU for medical treatment * Age ad admission \<48 hours * Written parental informed consent Part C: * ELGANs 22(+5)-27(+6) weeks (days) gestation admitted to the NICU * Decision to conduct full life support * Written parental informed consent Exclusion criteria (Part A, B, C) * No decision to conduct full life support * No parental written informed consent * Congenital malformations * Family history of hemoglobinopathies (e.g. sickle cell anemia, thalassemia) * Fetal anemia requiring in-utero A-RBC transfusions
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What it tests

  • Peroxide analysis-TOC Omnignostica Forschungs GmbH
  • Near Infrared Imaging
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Where

1 site
Divison of Neonatology, Department of Pediatrics, Medical University of Graz
Graz, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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