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Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis

RecruitingNAAges 18 Years - 65 YearsAllMarmara University
NCT07672873 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth. Failure to achieve profound anesthesia may result in increased intraoperative pain and patient discomfort. Corticosteroids have been suggested as adjunctive agents to improve pain control and reduce inflammatory responses; however, the influence of different local administration techniques on anesthetic success and postoperative pain remains unclear. The aim of this randomized controlled clinical trial is to compare the effects of submucosal and intraligamentary dexamethasone administration on anesthetic success and pain control in patients with symptomatic irreversible pulpitis. A total of 84 participants requiring root canal treatment of mandibular first or second molars diagnosed with symptomatic irreversible pulpit

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 to 65 years. * ASA I or ASA II systemic health status. * Symptomatic irreversible pulpitis in a mandibular molar tooth. * Positive response to pulp sensibility tests. * Preoperative pain score greater than 54 mm on the Heft-Parker Visual Analog Scale (HP-VAS). * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Pregnancy or lactation. * Allergy or contraindication to articaine, dexamethasone, or study-related medications. * Use of analgesics, anti-inflammatory drugs, or antibiotics within the previous 12 hours. * Presence of periapical radiolucency or diagnosis of pulpal necrosis. * Significant systemic disease (ASA III or higher). * Inability to complete pain assessment forms or follow study procedures.
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What it tests

  • Saline (0.9%, sterile, for infusion)
  • Dexamethasone
  • Dexamethasone
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Where

1 site
Marmara University Faculty of Dentistry
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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