Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation

Inclusion Criteria: * Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery. * Age of subject is ≥ 18 years. * Subject is female or male. * Capacity to consent. * Signed written informed consent. * For female subjects: 1. Confirmed post-menopausal state, defined as amenorrhea for at least 12 months, or 2. If being of childbearing potential: Negative highly sensitive urine or serum pregnancy test before inclusion. Exclusion Criteria: * Concurrent multiple solid organ or tissue transplants. * Prior history of any organ or cellular transplantation. * Subject suffers from an addiction or from a disease that prevents the subject from recognising nature, scope, and consequences of the study. * Subject shows an inability to comply with all the study procedures and follow-up visits. * Subject is legally detained in an official institution. * Subjects who are unwilling to consent to saving and propagation of pseudonymised medical data for study reasons. * Subject is financially dependent on the investigators or the study site.