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Helichrysum Italicum Extract in Irritant Contact Dermatitis

RecruitingNAAges 18 Years - 50 YearsAllUniversity of Split, School of Medicine
NCT07676253 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate the efficacy and safety of a topical cream containing Immortelle (Helichrysum italicum) extract in promoting skin barrier recovery and reducing signs of irritant contact dermatitis in healthy adult participants. The main questions it aims to answer are: * Does topical application of Helichrysum italicum extract improve skin barrier recovery following experimentally induced irritant contact dermatitis? * Does the cream containing Helichrysum italicum extract reduce transepidermal water loss and erythema, and improve skin hydration compared to a standard moisturizing cream? * Is the topical application of Helichrysum italicum extract safe and well tolerated? Researchers will compare skin sites treated with a cream containing Helichrysum italicum extract, placebo-treated skin sites, and untreated skin sites to determine whether the addition

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📋 Eligibility rules (as published)
Inclusion Criteria: * healthy volunteers who gave written informed consent Exclusion Criteria: * skin disease * skin damage on measurement sites * use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial * pregnancy or breastfeeding * immunosuppression * allergic or irritant reactions to the constituents of the cream
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What it tests

  • Helichrysum italicum Extract Cream
  • Placebo Cream
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Where

1 site
University of Split School of Medicine
Split, Croatia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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