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Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation

RecruitingNAAges 18 Years - 70 YearsAllUniversity of Gaziantep
NCT07678073 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes. Ferroptosis has recently emerged as a potential mechanism involved in ischemia-reperfusion injury, while the mitochondrial-derived peptides humanin and MOTS-c are thought to exert protective effects against oxidative stress. However, the effects of different anesthetic techniques on these biomarkers in kidney transplant recipients have not been investigated. This prospective controlled study aims to compare the effects of sevoflurane general anesthesia (SGA) and combined spinal-epidural anesthesia (CSEA) on serum ferroptosis markers, humanin, and MOTS-c levels in adult kidney transplant recipients. Blood samples will be obtained perioperatively for biomarker analysis. The primary objectiv

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III. * Patients scheduled for elective living-donor allogeneic kidney transplantation. * Patients receiving sevoflurane-based general anesthesia as the anesthetic technique. * Patients receiving combined spinal-epidural anesthesia as the anesthetic technique. Exclusion Criteria: * Patients younger than 18 years or older than 70 years. * Patients undergoing deceased-donor kidney transplantation. * Patients receiving total intravenous anesthesia (TIVA). * Patients who decline to participate in the study or are unable to provide informed consent. * Patients with American Society of Anesthesiologists (ASA) physical status IV or V. * Patients with a history of previous organ transplantation. * Patients with known or suspected mitochondrial disorders. * Patients with a history of chronic corticosteroid use. * Patients requiring red blood cell transfusion intraoperatively or within the first 24 postoperative hours. * Patients with a primary warm ischemia time \>5 minutes, secondary warm ischemia time \>30 minutes, or cold ischemia time \>60 minutes.
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What it tests

  • Sevoflurane General Anesthesia
  • Bupivacaine and Morphine for Combined Spinal-Epidural Anesthesia
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Where

1 site
Gaziantep University Faculty of Medicine Hospital
Gaziantep, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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