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The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk

Recruitingn/aAges 20 Years - 30 YearsAllUniversity Ghent
NCT07678736 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Insulin resistance is an early etiological factor in the development of type-2 diabetes (T2D), which constitutes a large societal health burden with an expected additional rise in the years to come. Skeletal muscle is the body's largest lean tissue mass and the major site of glucose disposal in response to insulin stimulation. Prior studies have suggested that a fast skeletal muscle phenotype, including a predominant fast muscle fiber composition, reduced capillary density, low fat oxidation and muscle oxidative capacity may be implicated in insulin resistance and TD2 development. However, key questions pertain in relation to the cause and effect of these relationships as well as the interaction with potential confounders and effect-modifiers including life-style factors (e.g. diet and physical activity levels) and general participant characteristics (e.g. body composition and training

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sex: Males and females * Age: 20-30 years * BMI \<35 * Healthy (no diagnosed chronic disease) Exclusion Criteria: * Chronic disease deemed to affect study outcomes * Disease that increase haemorrhage risk * Daily intake of medication that could confound study outcomes * Regular smokers * Active pregnancy * Immobilization (inactivity due to injury or illness, e.g. cast or brace) for more than a week in the month prior to the study or for more than 4 weeks in the past 6 months prior to the study * Very high structured physical exercise level (\>10 h/week). * Participants not willing to adhere to standardized meal prescriptions included in the study protocols will also be excluded (due to e.g. allergies or specific dietary preferences)
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What it tests

  • Not listed
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Where

1 site
Ghent University
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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