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โ† Trials
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Phosphate in Acute Pancreatitis

RecruitingPhase 2Ages 18 Years - anyAllDuke University
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to learn if phosphate administration works to treat acute pancreatitis in adults presenting to the emergency department at Duke University Hospital. The main questions it aims to answer are: * Does having low phosphate levels increase the risk of acute pancreatitis and can giving phosphate through an IV make the illness less severe? * Is phosphate therapy practical to use, and what is the appropriate dose? * Is this study achievable, and how can the results help design a future randomized controlled trial to assess safety and effectiveness? Participants will: * Receive standard of care or intravenous (IV) phosphate during their hospital stay * Have blood samples collected during admission to monitor phosphorus levels * Complete follow-up assessments after hospital admission to evaluate how severe the illness is and the effects of phosphate supplementation

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Presenting to the emergency department (ED) with acute pancreatitis meeting 2 or more characteristics of: (1) typical, persistent, severe upper abdominal pain, (2) lipase or amylase levels at least three times greater than the upper limit of normal, and/or (3) characteristic findings on abdominal imaging) * Trial treatment can be initiated within 24 hours of hospital admission * Consent can be obtained from the patient or their legal representative Exclusion Criteria: Contraindications to injectable phosphate including: * Hyperkalemia * Hypercalcemia or significant hypocalcemia * Severe renal impairment (eGFR \<30 mL/min/1.73m2) or end-stage renal disease
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What it tests

  • Sodium Phosphate
  • Potassium Phosphate
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Where

1 site
Duke University Medical Center
Durham, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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