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โ† Trials
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The Effect of Braun Anastomosis on Delayed Gastric Emptying (DGE) in Reconstruction After Pancreaticoduodenectomy

RecruitingNAAges 18 Years - anyAllTianjin Medical University Cancer Institute and Hโ€ฆ
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In plain words

What the trial is, and whether it could suit you

Pancreaticoduodenectomy (PD) is the only curative procedure for periampullary malignant tumors. Although modern perioperative management has greatly reduced postoperative mortality, delayed gastric emptying (DGE) remains one of the most common and troublesome complications after PD, with an incidence up to 30%. DGE leads to abdominal distension, nausea, vomiting, intolerance of oral diet, prolonged hospital stay, increased medical costs, delayed adjuvant therapy initiation, and impaired long-term nutritional recovery and quality of life. Braun anastomosis (BE) can reconstruct the gastrointestinal tract by side-to-side jejunojejunostomy between the afferent and efferent limbs, which may reduce intestinal stasis, bile reflux and afferent limb obstruction, and theoretically lower the risk of postoperative DGE. However, current clinical studies and meta-analyses remain controversial regardi

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age โ‰ฅ 18 years, male or female; * Scheduled to undergo curative pancreaticoduodenectomy (PD); * Undergoing PD for malignant or borderline tumors, with planned antecolic Billroth II reconstruction; * Mentally competent and able to provide written informed consent. Exclusion Criteria: * Age \< 18 years; * Prior diagnosis of gastroparesis; * Benign disease as the indication for PD; * Previous history of upper gastrointestinal surgery; * Preoperative pyloric obstruction; * Planned pylorus-preserving pancreaticoduodenectomy (PPPD); * Patients who have received neoadjuvant or conversion therapy; * Preoperative glycated hemoglobin (HbA1c) \> 7.5%; * Preoperative total bilirubin level \> 200 ฮผmol/L; * Unable or unwilling to provide written informed consent.
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What it tests

  • Braun anastomosis on delayed gastric emptying (DGE) in reconstruction after pancreaticoduodenectomy
  • Patients undergo PD with standard antecolic Billroth II reconstruction without Braun enteroenterostomy.
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Where

1 site
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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