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Belief Update: The Effects of Depression and Antidepressants in Older People

RecruitingNAAges 65 Years - anyAllHospital Center Guillaume Régnier
NCT07681492 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment with antidepressants. Research shows that past negative experiences with medication can reduce the effectiveness of treatment, whilst positive expectations can increase it. It is important to gain a better understanding of how antidepressants influence the way in which elderly people with major depressive disorder (MDD) change their beliefs, and to determine whether an improvement in their depressive symptoms is linked to these changes in their beliefs. This study aims to understand whether antidepressants can alter the way people view the future and whether this contributes to their effectiveness. It also seeks to determine whether patients' expectations regard

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📋 Eligibility rules (as published)
Inclusion Criteria for patients with major depressive disorder : * Patient over 65 years old in outpatient care * Patients with major depressive disorder or patients with bipolar major depressive disorder as evaluated by the Mini International Neuropsychiatric Interview (MINI) semi-structured interview for the group suffering from depression * Absence of cognitive impairment as evidenced by an MMSE (Mini Mental State Examination) ≥ 24 * MADRS ≥ 20 * MMSE ≥ 24 * Change of antidepressants * Person affiliated with a social security scheme * Patients who have received informed information about the study and have signed a consent form to participate in the study Exclusion Criteria with major depressive disorder : * mental disorders other than mood disorders : attention deficit dissorder, borderline personality disorder, schizophrenia, autism spectrum disorder, anorexia-bulimia disorder, obsessive-compulsive disorder, anxiety disorders and substance use disorder (except tobacco). * Inability to understand task instructions and perform the behavioral task * Neurological or neurosurgical comorbidities * Major visual impairment * Adults under state medical aid * Adults under legal protection (legal guardianship, curatorship, trusteeship), persons deprived of their liberty Inclusion Criteria for patients with major depressive disorder : * Absence of psychiatric disorders attested by administration of the MINI * Absence of cognitive impairment as evidenced by an MMSE ≥ 24
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What it tests

  • Response to questionnaire
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Where

2 sites
Centre Hospitalier Guillaume Regnier
Rennes, France
Centre Hospitalier Guillaume Régnier
Rennes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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