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Etiologic Diagnosis Algorithm in Infective Endocarditis

RecruitingNAAges 18 Years - anyAllI.M. Sechenov First Moscow State Medical Universi…
NCT07682389 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis

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📋 Eligibility rules (as published)
Inclusion Criteria: * Informed consent, * Age ≥ 18, * IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis) Exclusion Criteria: * Pregnancy/breastfeeding * Unconfirmed or rejected IE diagnosis, * Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion; * Prior use of antibiotic therapy (except documented treatment failure).
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What it tests

  • Molecular tests (PCR, sequencing)
  • Standard Clinical Practice
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Where

3 sites
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health
Moscow, Russia
City Clinical Hospital Named After S. S. Yudin
Moscow, Russia
City Clinical Hospital №67 Named After L. A. Vorokhobova
Moscow, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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