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Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery

Recruitingn/aAges 18 Years - anyAllUniversity of Roma La Sapienza
NCT07683962 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy, and identifies patient-related, site-specific, and technique-related factors associated with optimal early wound healing, in patients with Stage III-IV periodontitis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of Stage III or IV Periodontitis. * Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] \>= 6 mm, radiographic depth \>= 3 mm). * Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \< 15% at the time of surgery. Exclusion Criteria: * Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (\>10 cigarettes/day); pregnancy or lactation. * Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.
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What it tests

  • Periodontal Regenerative Therapy
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Where

1 site
Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology
Rome, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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