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Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers

Recruitingn/aAges 18 Years - anyAllHospital Center Guillaume Régnier
NCT07684911 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Despite advances in the effective treatment of major depressive disorder using repetitive transcranial magnetic stimulation (rTMS), the processes that determine a patient's response trajectory remain poorly understood. Currently, there are no validated clinical or neurophysiological markers that can identify factors predicting the durability of the response to rTMS at the individual level. This constitutes a major limitation for planning individualised treatments and highlights the need for precision medicine approaches and reliable biomarkers to predict the long-term efficacy of TMS-based interventions, thereby enabling more informed clinical decisions and optimised resource allocation. rTMS is assumed to work by inducing neuroplasticity on multiple levels of the nervous system, ranging from modulating neurotransmitter release to changing structural and functional brain circuits. Whil

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 or older. * Patients who have experienced treatment-resistant unipolar or bipolar depression and responded to a previous TMS course (response defined by a 50% reduction in MADRS score). * Sufficient command of French to complete questionnaires and follow instructions during MRI assessments and TMS treatments. * Willingness to comply with all study procedures, including availability for the duration of the study, and to communicate with study staff about adverse events and other clinically relevant information. * Patients who have expressed their informed written consent to participate in the study. * Person affiliated with a social welfare scheme or other scheme. Non-inclusion Criteria: * Current psychiatric comorbidity (suicidal risk, psychotic episode). * Unstable somatic pathology: active cancer, unstabilized endocrinological pathology, untreated sleep apnea. * For neuroimaging: Contraindications to magnetic resonance imaging (MRI) such as ferromagnetic metal in the body or severe claustrophobia * Adults under legal protection (legal guardianship, conservatorship, trusteeship), persons deprived of their liberty * Pregnancy or breast-feeding.
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What it tests

  • Repetitive transcranial magnetic stimulation
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Where

1 site
Centre Hospitalier Guillaume Régnier
Rennes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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