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Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age

RecruitingNAAges 35 Years - 45 YearsFemaleKaohsiung Veterans General Hospital.
NCT07685431 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respiratory chain activity and ATP production. This prospective study will enroll 60 infertile women aged 35-45 years undergoing in vitro fertilization (IVF) treatment. Thirty participants will receive oral ALA 600 mg/day for two months before their IVF cycle, and thirty will proceed directly to IVF without supplementation. The study will compare oocyte and embryo quality, cumulus cell mitochondrial function and metabolic gene expression, and clinical pregnancy and live birth rates between the two group

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 35-45 years * BMI 18-35 kg/m² * Planning to undergo IVF treatment using own oocytes Exclusion Criteria: * Primary ovarian insufficiency * Azoospermia or severe male-factor infertility in the partner * Congenital uterine anomaly * Severe intrauterine adhesion * Known chromosomal anomaly in either partner * Malignancy * Recipient of donor oocytes * Known hypersensitivity/allergy to alpha-lipoic acid
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What it tests

  • Alpha-Lipoic Acid (ALA)
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Where

1 site
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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