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Precision Management of Urinary Tract Symptoms in Older Women

RecruitingPhase 3Ages 65 Years - anyFemaleMegan Bradley
NCT07686055 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project aims to improve the diagnosis and management of urinary tract symptoms in older women by comparing three common treatment strategies-empiric antibiotics, urinalysis-guided therapy, and culture-directed care-in a randomized trial. By integrating patient-reported outcomes, laboratory data, the study will identify which patients benefit from antibiotics and which can safely avoid them. Findings will inform precision care strategies and promote antibiotic stewardship while improving symptom outcomes and quality of life in this high-risk population.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female biologic Sex * Age ≥65 years old * History of recurrent UTI per patient report of greater than 2 UTIs in the last 6 months or 3 UTIs in the last year * Patient reported UTI defined as: * Dysuria, increased urinary urgency/frequency and/or suprapubic pain Exclusion Criteria: * Male biologic sex * Age \<65 years old * History of augmentation cystoplasty or cystectomy * Currently performing clean intermittent self-catheterization * Current indwelling foley catheter * Urinary tract instrumentation (i.e., cystourethroscopy, foley catheter placement) in the last 30 days * Undergoing treatment for malignancy * History of either confirmed or patient reported pyelonephritis and/or urosepsis * Cirrhosis and/or end stage liver disease * Chronic kidney disease with most recent estimated glomerular filtration rate \<50 ml/min * Dementia and/or currently reside in skilled nursing facility * Current high-dose chronic steroids (\>20mg/day of prednisone) * Previous solid organ transplant * Provider concern for pyelonephritis and/or sepsis (i.e., fevers) * Unwilling or unable to comply with study procedures (including ability to complete electronic questionnaires)
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What it tests

  • Antibiotics
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Where

1 site
UPMC-Magee Womens Hospital
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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