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The Role That Food and Bacteria Play in Generating Abdominal Pain

RecruitingNAAges 18 Years - 70 YearsAllDavid Reed
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In plain words

What the trial is, and whether it could suit you

Irritable Bowel Syndrom (IBS) affects up to five percent of Canadians and has proven difficult to treat. Our research will explore how a type of dietary carbohydrate, called FODMAPS, contributes to chronic abdominal pain in irritable bowel syndrome (IBS). FODMAPs, are poorly digested carbohydrates and removing FODMAPs from the diet relieves abdominal pain in approximately half of IBS patients. Unfortunately, FODMAPs are contained in many foods, which makes it challenging for patients to remain on a low FODMAP diet for extended periods. Our proposed research will identify which subtypes of FODMAPs are most responsible for increasing pain and will tease apart whether the pain-causing effects of FODMAPs rely on the gut microbiota or not. To identify which specific type of FODMAP causes pain, IBS patients will adopt a low FODMAP diet and then individual FODMAP subtypes will be added back to

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18-70 with IBS (Rome IV (now V) criteria) * PROMIS belly pain score \>12 Exclusion Criteria: 1. Concurrent significant organic GI pathology (i.e. celiac, IBD, etc.) as some symptoms may be related to their disease and not IBS. 2. Concurrent systemic disease and/or laboratory abnormalities considered by investigators to be risky or that could interfere with data collection. 3. Major gastrointestinal surgery (e.g. Roux en y, bowel resection) as symptoms may be related to previous surgery rather than IBS. 4. Body mass index above 35 kg/m2 as it is unknown how mediators in the GI tract that may be involved in pain signaling in the gut are affected by obesity. 5. History of active cancer in the last 5 years, other than basal cell cancer as the treatment may have impacted the GI tract. 6. Pregnant or breastfeeding women. 7. Active or recent participation (\< 1 month) in a clinical study. 8. Use of antibiotics, probiotics, during, or one month prior to the study as may affect gut microbiota. 9. Use of new medications less than 4 weeks prior to the study as may alter gut microbiota and/or IBS symptoms. 10. Allergies to any of the ingredients used in the study. 11. Any immune-compromising conditions as may affect GI symptoms. 12. Currently being treated for eating disorder, schizophrenia, psychosis or other acute mental disorders as participating in a diet challenge study may have negative impact on these disorders.
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What it tests

  • FODMAP Challenge
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Where

1 site
Hotel Dieu Hospital
Kingston, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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