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Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

RecruitingPhase 2Ages 18 Years - 80 YearsAllMedical University of South Carolina
NCT07689773 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with standard smell training (ST) to improve olfactory function. Participants will complete 8 weeks of at-home treatment and attend three in-person visits for assessment. Improvements in smell, mood, sleep, and quality of life will be measured.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-80 * Self-reported or medically documented smell loss * Treatment-seeking for their smell loss * Naïve to TNS * Able to comprehend English and provide informed consent Exclusion Criteria: * Medical Records not available to confirm eligibility * Documented/Suspected head injury (e.g. sport, accident, blast exposure) * Neurological disorder (e.g. epilepsy, neurodegenerative disorder) * Serious mental illness (e.g. schizophrenia, bipolar disorder) * Suicidal ideation within the last month * Current (≤6 months) and/or heavy cigarette smokers (i.e. ≥ 10 pack-years) * Oral/nasal steroids or other intranasal medications * Immunomodulatory medications * Pregnant or trying to become pregnant
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What it tests

  • Trigeminal Nerve Stimulation-enhanced Smell Training
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Where

1 site
Medical University of South Carolina
Charleston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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