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Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction

RecruitingNAAges 35 Years - 70 YearsAllPeking University Third Hospital
NCT07693049 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a continuous clinical disease spectrum integrating cardiovascular, renal, and metabolic disorders. Heart failure with preserved ejection fraction (HFpEF) is considered Stage 4 of CKM syndrome, characterized primarily by impairment of cardiac structure and function. Numerous studies have confirmed that exercise intervention is effective in improving metabolic profiles and inflammatory status in Stages 0-3 of CKM syndrome (e.g., obesity, metabolic syndrome, hypertension, and diabetes), and significantly improves clinical outcomes. However, for Stage 4 CKM syndrome, especially in patients with HFpEF, conventional exercise prescription faces significant challenges in balancing safety and efficacy. Moreover, traditional "one-size-fits-all" exercise rehabilitation strategies have failed to significantly improve clinical outcomes due to the lack

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Men and women aged 35-70 years; 2. Physical inactivity / sedentary lifestyle defined as: Sedentary behavior: average daily sitting time \> 6 hours over the past 6 months; AND/OR Insufficient physical activity: average weekly moderate-intensity physical activity \< 150 minutes or vigorous-intensity physical activity \< 75 minutes as assessed by the International Physical Activity Questionnaire (IPAQ); 3. Patients with HFpEF at Stage 4 of CKM syndrome who have been clinically stable within the past month (New York Heart Association \[NYHA\] functional class II-III); 4. Willingness to improve health status through appropriate exercise. Exclusion Criteria: 1. Presence of contraindications to cardiopulmonary exercise testing (CPET); 2. Positive findings on the exercise electrocardiogram (ECG) during CPET; 3. Diagnosis of psychiatric disorders; 4. Presence of movement disorders or lower extremity exercise-related injuries within the past 6 months; 5. Women who are pregnant, breastfeeding, or planning to become pregnant in the near future; 6. Other conditions deemed unsuitable for participation in this study by the investigators; 7. Refusal to sign the informed consent form.
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What it tests

  • High-intensity interval training
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Where

13 sites
Beijing Chao-Yang Hospital, Capital Medical University
Beijing, China
Beijing Hospital
Beijing, China
Beijing Xiaotangshan Hospital
Beijing, China
Beijing Zhongguancun Hospital
Beijing, China
Community Health Station of the Party School of the Central Committee of C.P.C
Beijing, China
Jimenli Community Health Service Center
Beijing, China
Peking University First Hospital
Beijing, China
Peking University People's Hospital
Beijing, China

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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