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Metformin in Pseudomyxoma Peritonei Secondary to Appendiceal Mucinous Neoplasms

RecruitingPhase 2Ages 18 Years - anyAllUniversity of California, Irvine
NCT07693452 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a pilot, open-label clinical trial determining the feasibility of metformin therapy in subjects with pseudomyxoma peritonei (PMP) secondary to appendiceal mucinous neoplasms (AMNs).

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📋 Eligibility rules (as published)
Key Inclusion Criteria (complete details available in protocol): * Patients with clinical diagnosis of pseudomyxoma peritonei (PMP) secondary to presumed appendiceal mucinous neoplasms (AMNs) with recurrent/refractory disease s/p cytoreductive surgery(CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC), unresectable disease, or without planned CRS/HIPEC * Age ≥18 years * ECOG performance status ≤2 Key Exclusion Criteria (complete details available in protocol): * Patients with a clinical diagnosis of PMP secondary to presumed AMNs with resectable disease who are planned to undergo CRS/HIPEC * Patients currently taking metformin for another medical indication * Patients with a prior adverse event to administration of metformin
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What it tests

  • Metformin
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Where

1 site
Chao Family Comprehensive Cancer Center, University of California, Irvine
Orange, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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