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Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

RecruitingNAAges 18 Years - 60 YearsAllAlexandria University
NCT07693621 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18-60 years * ASA physical status I-II * scheduled for elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * Known hypersensitivity to study drugs * history of cardiac arrhythmias or conduction abnormalities * severe hepatic/renal impairment * chronic opioid or analgesic use * pregnancy * conversion to open surgery * drain insertion.
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What it tests

  • Bupivacaine 100 mg + dexmedetomidine 1 µg/kg
  • Bupivacaine 100 mg + magnesium sulphate 50 mg/kg
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Where

1 site
Alexandria University
Alexandria, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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